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After Treatment Completion

Frozen Embryo Thawing and Transfer

  • Standard technique for patients who were able to store embryos prior to undergoing treatment
  • Must have a functioning uterus to carry the frozen/thawed embryo
  • Patient must use estrogen and progesterone supplementation in order to prepare the lining of the uterus to accept and carry the embryo during the first few weeks of pregnancy
  • Overall frozen embryo survival ranges from 50%-70%
  • Pregnancy rates per frozen embryo transfer range from 10-40%, depending on the age of the patient at the time of her egg collection, fertilization and embryo freezing
  • Costs: Frozen Embryo Transfer charges range from $2,000-$4,000 plus about $2,000-$3,000 for medications.

Frozen Egg Thawing, In Vitro Fertilization and Embryo Transfer

  • Investigational (research) technique which requires Institutional Review Board approval
  • This technique is for patients who, after informed consent,  were able to freeze eggs prior to undergoing treatment
  • Requires several steps: Thawing of the eggs, In Vitro Fertilization of the eggs with the partner's sperm or the sperm of an anonymous sperm donor, and Embryo transfer
  • Must have a functioning uterus to carry the embryo
  • Patient must use estrogen and progesterone supplementation in order to prepare the lining of the uterus to accept and carry the embryo during the first few weeks of pregnancy Approximately 2-5% live birth rate per thawed oocyte (>200 live births reported)
  • Pregnancy rates per embryo transfer vary according to freezing technique:
    • Computerized slow egg freezing 1-10%
    • Immediate egg vitrification 20-40%
    • In Vitro Maturation and immediate egg vitrification 10-20%
  • Costs: Egg thawing and In Vitro Fertilization charges range from $1,500-$2,000. In addition, Embryo Transfer charges range from $1,500-$2,000 plus about $2,000-$3,000 for medications

Egg Donation

  • Standard technique for patients who have premature ovarian failure after treatment and desire to use donor eggs
  • UIC has had an active egg donation program for more than 15 years
  • Patient needs to recruit a known or an anonymous egg donor and the eggs can then be fertilized with either her partner's sperm or an anonymous donor's frozen sperm
  • Patient will be able to carry the baby, but she will not have the same genetic relationship to her child
  • The donor has to undergo ovarian stimulation with fertility drugs and egg retrieval
  • Patient must have a functioning uterus to carry the baby
  • Patient must use estrogen and progesterone supplementation in order to prepare the lining of the uterus to accept and carry the embryo during the first few weeks of pregnancy
  • Pregnancy rates per donor embryo transfer range from 35-50%, depending on the age of the egg donor
  • Counseling should be considered by couples considering egg donation due to the emotional stress involved
  • Costs: Anonymous egg donor charges range from $12,000-$15,000. In addition, charges for ovarian stimulation, egg retrieval and fertilization, and embryo transfer range from 15,000-20,000

Embryo Donation

  • Standard technique for patients who develop premature ovarian failure after treatment and desire to use donor embryos.
  • Frozen donor embryos are donated to help childless couples 
  • Patient and her partner will be able to have the baby, but neither of them will have the same genetic relationship to their child
  • Must have a functioning uterus to carry the donated embryo
  • Patient must use estrogen and progesterone supplementation in order to prepare the lining of the uterus to accept and carry the embryo during the first few weeks of pregnancy
  • Pregnancy rates per frozen donor embryo transfer range from 10-40%, depending on the age of the embryo donor
  • Counseling should be considered by couples considering embryo donation due to the emotional stress involved
  • Costs: Frozen Donor Embryo charges range from $2,000-$7,000. In addition, the costs for frozen embryo transfer range from $2,000-$4,000 plus about $2,000-$3,000 for medications.

Gestational Surrogacy

  • Standard technique for patients who are unable to carry a pregnancy
  • A gestational surrogate is a woman who is willing to carry the pregnancy, but has no genetic relationship to the child
  • The child has the same genetic makeup of the couple, but not of the surrogate
  • Patients may also choose to use donor eggs and/or donor sperm in order to produce embryos, which can then be transferred to the gestational surrogate
  • Pregnancy rates per embryo transfer range from 10-40%, depending on the age of the patient who is having the eggs retrieved
  • Patients considering gestational surrogacy should contact a reproductive rights attorney in order to understand the surrogacy laws in their state
  • Counseling should also be considered by couples considering gestational surrogacy due to the emotional stress involved
  • Costs: Gestational Surrogacy charges range from $50,000-$100,000

Adoption

  • Standard procedure to help couples who would otherwise not be able to have a baby
  • For a domestic adoption a couple needs to decide between an independent (non-agency) adoption and an agency adoption. There are also not-for-profit and for-profit organizations
  • For an international adoption a couple will be adopting a child from another country and will need to follow the laws of that country
  • Clearly a couple considering adoption will need proper legal advice in order to undertake this process
  • The adoption process takes between 1-5 years
  • Counseling should be considered by couples considering adoption due to the emotional stress involved
  • Resolve is a national infertility association which can offer practical guidance to couples seeking to pursue adoption. For more information please visit resolve.org
  • The American Society for Reproductive Medicine www.asrm.org also provides patient information and has a fact sheet on adoption which may be helpful to couples considering this process
  • Costs: An agency or international adoption plus legal advice charges may range between $15,000-$25,000

Ovarian Tissue Thawing

  • Investigational (research) technique for patients who were able to freeze and store strips of ovarian tissue prior to undergoing treatment
  • There are several ways in which the thawed ovarian tissue can be used:
    • Reimplantation of a strip of ovarian tissue back into the pelvis followed by either natural conception or In Vitro Fertilization and Embryo Transfer
    • Insertion of a strip of ovarian tissue under the skin in the arm or in the abdomen followed by In Vitro Fertilization and Embryo Transfer
    • Retrieval of immature eggs from the thawed ovarian tissue and In Vitro Maturation in the laboratory followed by fertilization and embryo transfer
  • There is a risk that the ovarian tissue that is being reimplanted after cancer treatment may contain some cancer cells and the cancer may recur
  • Subsequent surgical placement back in the body after cancer treatment
  • Ovarian transplant lifespan: 3 months to 3years
  • As of 2007 six live births reported
  • Costs: The surgery to reimplant the ovarian tissue in the pelvis is about $13,000-$15,000. In Vitro Maturation of the eggs, fertilization and embryo transfer charges are about $10,000.