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The Pediatric Pulmonary Research Center is involved in basic and translational research in neonatal and pediatric lung diseases, such as Neonatal Pulmonary Hypertension and Chronic Lung Disease, in collaboration with the Department of Pharmacology and Medicine and the Institute for Personalized Respiratory Medicine.

The Center for Neonatal and Pediatric Gastrointestinal Disease is engaged in both basic and translational research on the development and immunology of the gut in infants and children and diseases such as Neonatal Necrotizing Enterocolitis. This center supports the pediatric living bowel transplant program.

TIKES (Thriving Illinois Kids Engagement System) is a unified system of clinical care, education, and research that is focused on maximizing healthy developmental progress and social capital formation, using information technology to identify and deploy interventions for at-risk Illinois children and families. Three clinical trial programs are ongoing.